Description： Lotilaner belongs to the isoxazoline class of compounds. It is an ectoparasiticide used primarily in the veterinary field and is widely used as an antiparasitic agent to treat flea and tick infestations in animals. Lotilaner acts as a potent noncompetitive antagonist of insect GABAC1 receptors.

  Lotilaner is an effective, non competitive insect GABACl receptor antagonist with an IC50 value of 23.84 nM against fruit fly GABA receptors. There is no significant effect on GABAA in domestic dogs.