Nicotinamide mononucleotide, also known as β-nicotinamide mononucleotide (NMN), is a synthetic substrate of coenzyme I. At the same time, NMN is also used in anti-aging research. Studies have shown that β-NMN can also regulate the secretion of insulin and affect the expression level of mRNA. β-NMN has broad application prospects in the field of medical treatment. β-Nicotinamide mononucleotide Chemicalbook acid is a product of the extracellular nicotinamide phosphoribosyltransferase (eNAMPT) reaction and a key NAD+ intermediate. It improves glucose tolerance by restoring NAD+ levels in HFD-induced T2D mice. It also enhances hepatic insulin sensitivity and restores gene expression related to oxidative stress, inflammatory response and circadian rhythm in part through SIRT1 activation.