NooglutilexhibitspharmacologicallysignificantcompetitionwithaselectiveagonistofAMPAreceptors([G-3H]Ro48-8587)forthereceptorbindingsites(withIC50=6.4+/-0.2microM),whilethecompetitionofnoopeptforthesereceptorbindingsiteswaslowerbyanorderofmagnitude(IC50=80+/-5.6microM)[1].GVS-111significantlyincreasedneurChemicalbookonalsurvivalafterH(2)O(2)-treatmentdisplayingadose-dependentneuroprotectiveactivityfrom10nMto100microM,andanIC(50)valueof1.21+/-0.07microM.GVS-111inhibitedtheaccumulationofintracellularfreeradicalsandlipidperoxidationdamageinneuronstreatedwithH(2)O(2)orFeSO(4),suggestinganantioxidantmechanismofaction[2].