NR-CL has been implicated in increasing tissue NAD concentrations and inducing insulin sensitivity as well as enhancing sirtuin function. Its ability to increase NAD production suggests that NR-CL may also improve mitochondrial health, stimulate mitochondrial function, and induce the production of new mitochondria. Other studies using NR-CL in models of Alzheimer's disease have shown that the molecule is bioavailable to the brain and may provide neuroprotection by stimulating brain NAD synthesis.