Product name: Vardenafil hydrochloride trihydrate

Cas NO: 16545-68-9

M.F: C3H6O

M.W:58.08

Capacity: 200KG/M

UsageSexual Enhancement

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■ Description


Vardenafil hydrochloride trihydrate (BAY38-9456) is a novel PDE inhibitor that acts on PDE5 and PDE1 with IC50 of 0.7 and 180 nM, respectively.



Vardenafil hydrochloride specifically inhibits PDE5-mediated cGMP hydrolysis with an IC50 of 0.7nM (6.6nM). Vardenafi significantly enhanced SNP-induced relaxation of human trabecular smooth muscle at 3nM (10nM). Vardenafi significantly induced acetylcholine- and electrical stimulation-induced relaxation of trabecular smooth muscle. Vardenafil (100mM) increased cGMP levels in rat hippocampus. Vardenafil, tadalafil, and sildenafil competitively inhibit cGMP hydrolysis by phosphodiesterase 5 (PDE5), thereby promoting cGMP accumulation and relaxation in vascular smooth muscle.

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