13-0；4-[1-[3-(cyanomethyl)-1-(ethylsulfonyl)-3-azetidinyl]-1H-pyrazol-4-yl]-7H-Pyrrolo[2,3-d]pyrimidine-7-carboxylic acid 1,1-dimethylethyl ester

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Home > Products > Advanced Intermediates > Baricitinib Intermediate > 13-0；4-[1-[3-(cyanomethyl)-1-(ethylsulfonyl)-3-azetidinyl]-1H-pyrazol-4-yl]-7H-Pyrrolo[2,3-d]pyrimidine-7-carboxylic acid 1,1-dimethylethyl ester

Product name: 4-[1-[3-(cyanomethyl)-1-(ethylsulfonyl)-3-azetidinyl]-1H-pyrazol-4-yl]-7H-Pyrrolo[2,3-d]pyrimidine-7-carboxylic acid 1,1-dimethylethyl ester

Cas NO.: 2055723-13-0

M.F: C21H25N7O4S

M.W.: 471.53

Capacity: 1200KG/M

Usage: Baricitinib intermediate

Key intermediate for not patent ros of Baricitinib

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■ Description

Cas NO.: 2055723-13-0, this route used for Baricitinib is to be different from patent route (which still valid for at least 5 years).

To control the single impurity 0.1% of Baricitinib, it better controls it in the crucial baricitinib intermediate. The impurity in 2055723-13-0 is really hard to reduce in later steps (there is method reducing yet it yeilds less and costs more. very complex ).

We have stock of the intermediate and supplied to Egypt Big group EVA pharm. Any need, pls contact.

Product name	Cas No.
2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile	1187595-85-2
4-Pyrazoleboronic acid pinacol ester	269410-08-4
tert-butyl 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-7-carboxylate	1236033-21-8
3-Azetidineacetonitrile, 1-(ethylsulfonyl)-3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]-	1919837-50-5
4-[1-[3-(cyanomethyl)-1-(ethylsulfonyl)-3-azetidinyl]-1H-pyrazol-4-yl]-7H-Pyrrolo[2,3-d]pyrimidine-7-carboxylic acid 1,1-dimethylethyl ester	2055723-13-0

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